Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets.

Psaila, Bethan; Wang, Guanlin; Rodriguez-Meira, Alba; Li, Rong; Heuston, Elisabeth F; Murphy, Lauren; Yee, Daniel; Hitchcock, Ian S; Sousos, Nikolaos; O'Sullivan, Jennifer; Anderson, Stacie; Senis, Yotis A; Weinberg, Olga K; Calicchio, Monica L; Iskander, Deena; Royston, Daniel; Milojkovic, Dragana; Roberts, Irene; Bodine, David M; Thongjuea, Supat; Mead, Adam J.

Mol Cell ; 78(3): 477-492.e8, 2020 05 07.

Artigo em Inglês | MEDLINE | ID: mdl-32386542

2.

Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome".

Karisch, Robert; Fernandez, Minerva; Taylor, Paul; Virtanen, Carl; St-Germain, Jonathan R; Jin, Lily L; Harris, Isaac S; Mori, Jun; Mak, Tak W; Senis, Yotis A; Östman, Arne; Moran, Michael F; Neel, Benjamin G.

Cell ; 146(5): 826-40, 2011 Sep 02.

Artigo em Inglês | MEDLINE | ID: mdl-21884940

3.

Interplay between the tyrosine kinases Chk and Csk and phosphatase PTPRJ is critical for regulating platelets in mice.

Nagy, Zoltan; Mori, Jun; Ivanova, Vanesa-Sindi; Mazharian, Alexandra; Senis, Yotis A.

Blood ; 135(18): 1574-1587, 2020 04 30.

Artigo em Inglês | MEDLINE | ID: mdl-32016283

4.

Catalytic dysregulation of SHP2 leading to Noonan syndromes affects platelet signaling and functions.

Bellio, Marie; Garcia, Cédric; Edouard, Thomas; Voisin, Sophie; Neel, Benjamin G; Cabou, Cendrine; Valet, Philippe; Mori, Jun; Mazharian, Alexandra; Senis, Yotis A; Yart, Armelle; Payrastre, Bernard; Severin, Sonia.

Blood ; 134(25): 2304-2317, 2019 12 19.

Artigo em Inglês | MEDLINE | ID: mdl-31562133

5.

The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions.

Nagy, Zoltan; Vögtle, Timo; Geer, Mitchell J; Mori, Jun; Heising, Silke; Di Nunzio, Giada; Gareus, Ralph; Tarakhovsky, Alexander; Weiss, Arthur; Neel, Benjamin G; Desanti, Guillaume E; Mazharian, Alexandra; Senis, Yotis A.

Blood ; 133(4): 331-343, 2019 01 24.

Artigo em Inglês | MEDLINE | ID: mdl-30429161

6.

Lymphatic blood filling in CLEC-2-deficient mouse models.

Haining, Elizabeth J; Lowe, Kate L; Wichaiyo, Surasak; Kataru, Raghu P; Nagy, Zoltan; Kavanagh, Dean Pj; Lax, Sian; Di, Ying; Nieswandt, Bernhard; Ho-Tin-Noé, Benoît; Mehrara, Babak J; Senis, Yotis A; Rayes, Julie; Watson, Steve P.

Platelets ; 32(3): 352-367, 2021 Apr 03.

Artigo em Inglês | MEDLINE | ID: mdl-32129691

7.

Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis.

Geer, Mitchell J; van Geffen, Johanna P; Gopalasingam, Piraveen; Vögtle, Timo; Smith, Christopher W; Heising, Silke; Kuijpers, Marijke J E; Tullemans, Bibian M E; Jarvis, Gavin E; Eble, Johannes A; Jeeves, Mark; Overduin, Michael; Heemskerk, Johan W M; Mazharian, Alexandra; Senis, Yotis A.

Blood ; 132(13): 1413-1425, 2018 09 27.

Artigo em Inglês | MEDLINE | ID: mdl-29891536

8.

Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148.

Mori, Jun; Nagy, Zoltan; Di Nunzio, Giada; Smith, Christopher W; Geer, Mitchell J; Al Ghaithi, Rashid; van Geffen, Johanna P; Heising, Silke; Boothman, Luke; Tullemans, Bibian M E; Correia, Joao N; Tee, Louise; Kuijpers, Marijke J E; Harrison, Paul; Heemskerk, Johan W M; Jarvis, Gavin E; Tarakhovsky, Alexander; Weiss, Arthur; Mazharian, Alexandra; Senis, Yotis A.

Blood ; 131(10): 1122-1144, 2018 03 08.

Artigo em Inglês | MEDLINE | ID: mdl-29301754

9.

Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice.

Hofmann, Inga; Geer, Mitchell J; Vögtle, Timo; Crispin, Andrew; Campagna, Dean R; Barr, Alastair; Calicchio, Monica L; Heising, Silke; van Geffen, Johanna P; Kuijpers, Marijke J E; Heemskerk, Johan W M; Eble, Johannes A; Schmitz-Abe, Klaus; Obeng, Esther A; Douglas, Michael; Freson, Kathleen; Pondarré, Corinne; Favier, Rémi; Jarvis, Gavin E; Markianos, Kyriacos; Turro, Ernest; Ouwehand, Willem H; Mazharian, Alexandra; Fleming, Mark D; Senis, Yotis A.

Blood ; 132(13): 1399-1412, 2018 09 27.

Artigo em Inglês | MEDLINE | ID: mdl-29898956

10.

ITIM receptors: more than just inhibitors of platelet activation.

Coxon, Carmen H; Geer, Mitchell J; Senis, Yotis A.

Blood ; 129(26): 3407-3418, 2017 06 29.

Artigo em Inglês | MEDLINE | ID: mdl-28465343

11.

Evaluation of the Total Thrombus-Formation System (T-TAS): application to human and mouse blood analysis.

Al Ghaithi, Rashid; Mori, Jun; Nagy, Zoltan; Maclachlan, Annabel; Hardy, Lewis; Philippou, Helen; Hethershaw, Emma; Morgan, Neil V; Senis, Yotis A; Harrison, Paul.

Platelets ; 30(7): 893-900, 2019.

Artigo em Inglês | MEDLINE | ID: mdl-30365350

12.

Signalling through Src family kinase isoforms is not redundant in models of thrombo-inflammatory vascular disease.

Harrison, Matthew J; Chimen, Myriam; Hussain, Mohammed; Iqbal, Asif J; Senis, Yotis A; Nash, Gerard B; Watson, Steve P; Rainger, G Ed.

J Cell Mol Med ; 22(9): 4317-4327, 2018 09.

Artigo em Inglês | MEDLINE | ID: mdl-29974666

13.

Mice Lacking the Inhibitory Collagen Receptor LAIR-1 Exhibit a Mild Thrombocytosis and Hyperactive Platelets.

Smith, Christopher W; Thomas, Steven G; Raslan, Zaher; Patel, Pushpa; Byrne, Maxwell; Lordkipanidzé, Marie; Bem, Danai; Meyaard, Linde; Senis, Yotis A; Watson, Steve P; Mazharian, Alexandra.

Arterioscler Thromb Vasc Biol ; 37(5): 823-835, 2017 05.

Artigo em Inglês | MEDLINE | ID: mdl-28336561

14.

Targeting Receptor-Type Protein Tyrosine Phosphatases with Biotherapeutics: Is Outside-in Better than Inside-Out?

Senis, Yotis A; Barr, Alastair J.

Molecules ; 23(3)2018 Mar 02.

Artigo em Inglês | MEDLINE | ID: mdl-29498714

15.

Proplatelets slip slidin' away.

Mazharian, Alexandra; Senis, Yotis A.

Blood ; 125(5): 747-8, 2015 Jan 29.

Artigo em Inglês | MEDLINE | ID: mdl-25634614

16.

Src family kinases: at the forefront of platelet activation.

Senis, Yotis A; Mazharian, Alexandra; Mori, Jun.

Blood ; 124(13): 2013-24, 2014 Sep 25.

Artigo em Inglês | MEDLINE | ID: mdl-25115887

17.

TLT-1: please release me, let me go.

Senis, Yotis A.

Blood ; 132(23): 2427-2429, 2018 12 06.

Artigo em Inglês | MEDLINE | ID: mdl-30523125

18.

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function.

Mazharian, Alexandra; Mori, Jun; Wang, Ying-Jie; Heising, Silke; Neel, Benjamin G; Watson, Steve P; Senis, Yotis A.

Blood ; 121(20): 4205-20, 2013 May 16.

Artigo em Inglês | MEDLINE | ID: mdl-23509158

19.

Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.

Tautz, Lutz; Senis, Yotis A; Oury, Cécile; Rahmouni, Souad.

Bioorg Med Chem ; 23(12): 2786-97, 2015 Jun 15.

Artigo em Inglês | MEDLINE | ID: mdl-25921264

20.

Ups and downs of the ADP phosphoproteome.

Nagy, Zoltan; Senis, Yotis A.

Blood ; 129(2): 135-136, 2017 01 12.

Artigo em Inglês | MEDLINE | ID: mdl-28082287

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